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Article

Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts.

Journal of molecular evolution - 1 Apr 2013

Ramalho Rodrigo F, Gelfman Sahar, de Souza Jorge E, Ast Gil, de Souza Sandro J, Meyer Diogo

Abstract excerpt

Despite evidence that at the interspecific scale, exonic splicing silencers (ESSs) are under negative selection in constitutive exons, little is known about the effects of slightly deleterious polymorphisms on these splicing regulators. Through the application of a modified version of the McDonald-Kreitman test, we compared the normalized proportions of human polymorphisms and human/rhesus substitutions affecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23529588
DOI: 10.1007/s00239-013-9555-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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