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Article

Single nucleotide polymorphism-based validation of exonic splicing enhancers.

PLoS biology - 1 Sept 2004

Fairbrother William G, Holste Dirk, Burge Christopher B, Sharp Phillip A

Abstract excerpt

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (variant elimination reinforces functionality), which can be used to assess the extent of natural selection acting on an...

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Identifiers

PMID: 15340491
DOI: 10.1371/journal.pbio.0020268
PMCID: PMC514884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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