Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide polymorphism-based validation of exonic splicing enhancers.

PLoS biology - 1 Sept 2004

Fairbrother William G, Holste Dirk, Burge Christopher B, Sharp Phillip A

Abstract excerpt

Because deleterious alleles arising from mutation are filtered by natural selection, mutations that create such alleles will be underrepresented in the set of common genetic variation existing in a population at any given time. Here, we describe an approach based on this idea called VERIFY (varia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Amino Acid Motifs
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Genetic Techniques

Share to Oligonucleotides

Share to Pan troglodytes

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 15340491
DOI: 10.1371/journal.pbio.0020268
PMCID: PMC514884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15340491-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide polymorphism-based validation of exonic splicing enhancers.PMID 15340491Read ↗

The evolution, impact and properties of exonic splice enhancers.Semantic proximity Read ↗

Synonymous SNPs provide evidence for selective constraint on human exonic splicing enhancers.Semantic proximity Read ↗

Genomic features defining exonic variants that modulate splicing.Semantic proximity Read ↗

Genomic HEXploring allows landscaping of novel potential splicing regulatory elements.Semantic proximity Read ↗

Dual Function of DNA Sequences: Protein-Coding Sequences Function as Transcriptional Enhancers.Semantic proximity Read ↗

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases.Semantic proximity Read ↗

Human genetic variation recognizes functional elements in noncoding sequence.Semantic proximity Read ↗

Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences.Semantic proximity Read ↗

Mutations of Pre-mRNA Splicing Regulatory Elements: Are Predictions Moving Forward to Clinical Diagnostics?Semantic proximity Read ↗

Computational definition of sequence motifs governing constitutive exon splicing.Semantic proximity Read ↗

Systematic evaluation of the effect of common SNPs on pre-mRNA splicing.Semantic proximity Read ↗

A comprehensive survey of human polymorphisms at conserved splice dinucleotides and its evolutionary relationship with alternative splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.