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Article

Synonymous SNPs provide evidence for selective constraint on human exonic splicing enhancers.

Journal of molecular evolution - 1 Jan 2006

Carlini David B, Genut Jordan E

Abstract excerpt

The human SNP database was used to detect selection on 238 hexamers previously identified as exonic splicing enhancers (ESEs). We compared the distribution of the 238 putative ESEs in biallelic and triallelic SNPs within five different functional categories of the SNP database: synonymous, nonsynonymous, introns, UTRs, and nongenic SNPs. Since true ESEs do not function outside of exons, SNPs that disrupt ESE...

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Identifiers

PMID: 16320116
DOI: 10.1007/s00239-005-0055-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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