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Article

Evidence for purifying selection against synonymous mutations in mammalian exonic splicing enhancers.

Molecular biology and evolution - 1 Feb 2006

Parmley Joanna L, Chamary J V, Hurst Laurence D

Abstract excerpt

Silent sites in mammals have classically been assumed to be free from selective pressures. Consequently, the synonymous substitution rate (Ks) is often used as a proxy for the mutation rate. Although accumulating evidence demonstrates that the assumption is not valid, the mechanism by which selection acts remain unclear. Recent work has revealed that the presence of exonic splicing enhancers (ESEs) in coding...

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PMID: 16221894
DOI: 10.1093/molbev/msj035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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