Article
The "alternative" choice of constitutive exons throughout evolution.
PLoS genetics - 1 Nov 2007
Lev-Maor Galit, Goren Amir, Sela Noa, Kim Eddo, Keren Hadas, Doron-Faigenboim Adi, Leibman-Barak Shelly, Pupko Tal, Ast Gil
Abstract excerpt
Alternative cassette exons are known to originate from two processes-exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution. We compiled a dataset of orthologous exons from human and mouse that are constitutively spliced in one species but alternatively spliced in the other....
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