Article
Selection against archaic hominin genetic variation in regulatory regions
2019-07-19
Abstract excerpt
Traces of archaic hominin DNA persist in the human gene pool, but are systematically depleted around genes and other functionally important genomic regions. This suggests that many Neandertal and Denisovan alleles had harmful effects on hybrid fitness. We hypothesized that if some harmful effects were mediated by gene dysregulation in specific tissues, alleles previously flagged as archaic using a conditional rand...
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Identifiers and source
- Literature Corpus work
- 6b0abebe-fcd1-51fd-aa3a-5d0ac5034d36
- DOI
- 10.1101/708230