Article
Alternative splicing and genetic diversity: silencers are more frequently modified by SNVs associated with alternative exon/intron borders.
Nucleic acids research - 1 Jul 2011
de Souza Jorge E S, Ramalho Rodrigo F, Galante Pedro A F, Meyer Diogo, de Souza Sandro J
Abstract excerpt
With the availability of a large amount of genomic data it is expected that the influence of single nucleotide variations (SNVs) in many biological phenomena will be elucidated. Here, we approached the problem of how SNVs affect alternative splicing. First, we observed that SNVs and exonic splicing regulators (ESRs) independently show a biased distribution in alternative exons. More importantly, SNVs map more...
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