Article
The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Sved J, Bird A
Abstract excerpt
The CpG dinucleotide is present at approximately 20% of its expected frequency in vertebrate genomes, a deficiency thought due to a high mutation rate from the methylated form of CpG to TpG and CpA. We examine the hypothesis that the 20% frequency represents an equilibrium between rate of creation of new CpGs and accelerated rate of CpG loss from methylation. Using this model, we calculate the expected reduction...
Topics
- Animals
- Biological Evolution
- Dinucleoside Phosphates
- Factor IX
- Genomic Library
- Globins
- Models, Genetic
- Mutation
- Pseudogenes
- Time Factors
- Vertebrates