Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylation-driven model for analysis of dinucleotide evolution in genomes.

Theoretical biology & medical modelling - 8 Apr 2020

Sun Jian-Hong, Ai Shi-Meng, Liu Shu-Qun

Abstract excerpt

BACKGROUND: CpGs, the major methylation sites in vertebrate genomes, exhibit a high mutation rate from the methylated form of CpG to TpG/CpA and, therefore, influence the evolution of genome composition. However, the quantitative effects of CpG to TpG/CpA mutations on the evolution of genome composition in terms of the dinucleotide frequencies/proportions remain poorly understood. RESULTS: Based on the neutral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Dinucleoside Phosphates
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genome

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 32264909
DOI: 10.1186/s12976-020-00122-x
PMCID: PMC7140373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylation-driven model for analysis of dinucleotide evolution in genomes.PMID 32264909Read ↗

Genome-scale relationships between cytosine methylation and dinucleotide abundances in animals.Semantic proximity Read ↗

Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla--selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses.Semantic proximity Read ↗

DNA sequence evolution with neighbor-dependent mutation.Semantic proximity Read ↗

Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Semantic proximity Read ↗

The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model.Semantic proximity Read ↗

Investigating the relationship of DNA methylation with mutation rate and allele frequency in the human genome.Semantic proximity Read ↗

Evaluation of the effect of CpG hypermutability on human codon substitution.Semantic proximity Read ↗

Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns.Semantic proximity Read ↗

A neutrality test for detecting selection on DNA methylation using single methylation polymorphism frequency spectrum.Semantic proximity Read ↗

Comprehensive analysis of the base composition around the transcription start site in Metazoa.Semantic proximity Read ↗

Bayesian Markov chain Monte Carlo sequence analysis reveals varying neutral substitution patterns in mammalian evolution.Semantic proximity Read ↗

The tendency to recreate ancestral CG dinucleotides in the human genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.