Article
Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals.
BMC evolutionary biology - 30 Sept 2008
Gaffney Daniel J, Keightley Peter D
Abstract excerpt
BACKGROUND: Molecular evolutionary studies in mammals often estimate nucleotide substitution rates within and outside CpG dinucleotides separately. Frequently, in alignments of two sequences, the division of sites into CpG and non-CpG classes is based simply on the presence or absence of a CpG dinucleotide in either sequence, a procedure that we refer to as CpG/non-CpG assignment. Although it likely that this...
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