Article
Cytosine deamination plays a primary role in the evolution of mammalian isochores.
Molecular biology and evolution - 1 Sept 2000
Fryxell K J, Zuckerkandl E
Abstract excerpt
DNA melting is rate-limiting for cytosine deamination, from which we infer that the rate of cytosine deamination should decline twofold for each 10% increase in GC content. Analysis of human DNA sequence data confirms that this is the case for 5-methylcytosine. Several lines of evidence further confirm that it is also the case for unmethylated cytosine and that cytosine deamination causes the majority of all...
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