The mutational spectrum of non-CpG DNA varies with CpG content.

doi:10.1101/gr.103283.109

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Article

The mutational spectrum of non-CpG DNA varies with CpG content.

Genome research - 1 Jul 2010

Walser Jean-Claude, Furano Anthony V

Abstract excerpt

The accumulation of base substitutions (mutations) not subject to natural selection is the neutral mutation rate. Because this rate reflects the in vivo processes involved in maintaining the integrity of genetic information, the factors that affect the neutral mutation rate are of considerable interest. Mammals exhibit two dramatically different neutral mutation rates: the CpG mutation rate, wherein the C of most...

Topics

Animals
Base Composition
Base Sequence
CpG Islands
DNA
DNA Mutational Analysis
Genetic Speciation
Humans
Long Interspersed Nucleotide Elements
Mammals
Molecular Sequence Data
Mutation
Pan troglodytes

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Identifiers

PMID: 20498119
DOI: 10.1101/gr.103283.109
PMCID: PMC2892088

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