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The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.

Molecular biology and evolution - 1 Nov 2000

Duret L, Galtier N

Abstract excerpt

CpG and TpA dinucleotides are underrepresented in the human genome. The CpG deficiency is due to the high mutation rate from C to T in methylated CpG's. The TpA suppression was thought to reflect a counterselection against TpA's destabilizing effect in RNA. Unexpectedly, the TpA and CpG deficiencies vary according to the G+C contents of sequences. It has been proposed that the variation in CpG suppression was...

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PMID: 11070050
DOI: 10.1093/oxfordjournals.molbev.a026261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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