The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.

doi:10.1093/oxfordjournals.molbev.a026261

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Article

The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.

Molecular biology and evolution - 1 Nov 2000

Duret L, Galtier N

Abstract excerpt

CpG and TpA dinucleotides are underrepresented in the human genome. The CpG deficiency is due to the high mutation rate from C to T in methylated CpG's. The TpA suppression was thought to reflect a counterselection against TpA's destabilizing effect in RNA. Unexpectedly, the TpA and CpG deficiencies vary according to the G+C contents of sequences. It has been proposed that the variation in CpG suppression was...

Topics

Animals
Base Composition
CpG Islands
Dinucleotide Repeats
Evolution, Molecular
Genetic Variation
Genome, Human
Humans
Mathematics
Models, Genetic

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Open in PubMed

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PMID: 11070050
DOI: 10.1093/oxfordjournals.molbev.a026261

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