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Article

Why does the human factor IX gene have a G + C content of 40%?

American journal of human genetics - 1 Oct 1991

Bottema C D, Bottema M J, Ketterling R P, Yoon H S, Janco R L, Phillips J A, Sommer S S

Abstract excerpt

The factor IX gene has a G + C content of approximately 40% in all mammalian species examined. In human factor IX, C----T and G----A transitions at the dinucleotide CpG are elevated at least 24-fold relative to other transitions. Can the G + C content be explained solely by this hot spot of mutation? Using our mathematical model, we show that the elevation of mutation at CpG cannot alone lower the G + C content...

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Identifiers

PMID: 1897528
PMCID: PMC1683181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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