Why does the human factor IX gene have a G + C content of 40%?

Article

Why does the human factor IX gene have a G + C content of 40%?

American journal of human genetics - 1 Oct 1991

Bottema C D, Bottema M J, Ketterling R P, Yoon H S, Janco R L, Phillips J A, Sommer S S

Abstract excerpt

The factor IX gene has a G + C content of approximately 40% in all mammalian species examined. In human factor IX, C----T and G----A transitions at the dinucleotide CpG are elevated at least 24-fold relative to other transitions. Can the G + C content be explained solely by this hot spot of mutat...

Topics

Base Composition
Biological Evolution
Cytosine
Dinucleoside Phosphates
Factor IX
Guanine
Haplotypes
Hemophilia B
Humans
Models, Genetic
Models, Theoretical
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.