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Article

Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1992

Kricker M C, Drake J W, Radman M

Abstract excerpt

Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides in those DNA duplications that create uninterrupted homologous sequences longer than about 0.3 kilobases. The model...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1736289
DOI: 10.1073/pnas.89.3.1075
PMCID: PMC48388

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Source receipt: pubmed, retrieved 7 Sept 2026.

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