Article
Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1992
Kricker M C, Drake J W, Radman M
Abstract excerpt
Mammalian genomes are threatened with gene inactivation and chromosomal scrambling by recombination between repeated sequences such as mobile genetic elements and pseudogenes. We present and test a model for a defensive strategy based on the methylation and subsequent mutation of CpG dinucleotides in those DNA duplications that create uninterrupted homologous sequences longer than about 0.3 kilobases. The model...
Topics
- Animals
- Biological Evolution
- Chromosomes
- Eukaryotic Cells
- Genes
- Humans
- Methylation
- Multigene Family
- Mutation
- Pseudogenes
- Repetitive Sequences, Nucleic Acid