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Article

DNA sequence evolution with neighbor-dependent mutation.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2003

Arndt Peter F, Burge Christopher B, Hwa Terence

Abstract excerpt

We introduce a model of DNA sequence evolution which can account for biases in mutation rates that depend on the identity of the neighboring bases. An analytic solution for this class of models is developed by adopting well-known methods of nonlinear dynamics. Results are presented for the CpG-methylation-deamination process, which dominates point substitutions in vertebrates. The dinucleotide frequencies...

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PMID: 12935330
DOI: 10.1089/10665270360688039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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