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Article

Accurate estimations of evolutionary times in the context of strong CpG hypermutability.

Journal of computational biology : a journal of computational molecular cell biology - 1 May 2012

Falconnet Mikael, Behrens Sarah

Abstract excerpt

We consider the substitution model T92+CpG of DNA sequence evolution which takes into account the hypermutability of CpG dinucleotides, an effect that can be especially observed in vertebrate genomes. We provide an exact method to simulate the evolution of finite DNA sequences under this model and numerical procedures to infer evolutionary times in two cases: between an ancestral and a present sequence and...

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PMID: 22468680
DOI: 10.1089/cmb.2011.0135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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