Article
C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling.
Circulation research - 10 May 2013
Sciarretta Sebastiano, Marchitti Simona, Bianchi Franca, Moyes Amie, Barbato Emanuele, Di Castro Sara, Stanzione Rosita, Cotugno Maria, Castello Lorenzo, Calvieri Camilla, Eberini Ivano, Sadoshima Junichi, Hobbs Adrian J, Volpe Massimo, Rubattu Speranza
Abstract excerpt
RATIONALE: C2238 atrial natriuretic peptide (ANP) minor allele (substitution of thymidine with cytosine in position 2238) associates with increased risk of cardiovascular events. OBJECTIVE: We investigated the mechanisms underlying the vascular effects of C2238-αANP. METHODS AND RESULTS: In vitro, human umbilical vein endothelial cell were exposed to either wild-type (T2238)- or mutant (C2238)-αANP. Cell survival...
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