Article
The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177.
Bioscience reports - 6 Aug 2014
Wu Pei-Rung, Chen Bo-Rui, Hsieh Chi-Chun, Lin Wei-Chung, Wu Kenneth K, Hwu Yeukuang, Chen Pei-Feng
Abstract excerpt
NO production catalysed by eNOS (endothelial nitric-oxide synthase) plays an important role in the cardiovascular system. A variety of agonists activate eNOS through the Ser1177 phosphorylation concomitant with Thr495 dephosphorylation, resulting in increased ·NO production with a basal level of calcium. To date, the underlying mechanism remains unclear. We have previously demonstrated that perturbation of the...
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