Article
C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro.
Cell death & disease - 31 Dec 2015
Stanzione R, Sciarretta S, Marchitti S, Bianchi F, Di Castro S, Scarpino S, Cotugno M, Frati G, Volpe M, Rubattu S
Abstract excerpt
Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified. In the present work we aimed at exploring the impact of C2238/αANP (mutant form) on atherosclerosis-related pathways. As a first step, an atherosclerosis gene expression macroarray analysis was...
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