Article
Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011
Oganesian Anush, Yarov-Yarovoy Vladimir, Parks William C, Schwinn Debra A
Abstract excerpt
We previously identified a naturally occurring human SNP, G247R, in the third intracellular loop of the α(1a)-adrenergic receptor (α(1a)-247R) and demonstrated that constitutive expression of α(1a)-247R results in twofold increased cell proliferation compared with WT. In the present study we elucidate molecular mechanisms and signal transduction pathways responsible for increased cell proliferation unique to...
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