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Article

Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011

Oganesian Anush, Yarov-Yarovoy Vladimir, Parks William C, Schwinn Debra A

Abstract excerpt

We previously identified a naturally occurring human SNP, G247R, in the third intracellular loop of the α(1a)-adrenergic receptor (α(1a)-247R) and demonstrated that constitutive expression of α(1a)-247R results in twofold increased cell proliferation compared with WT. In the present study we eluc...

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Source

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Identifiers

PMID: 22089237
DOI: 10.1073/pnas.1116271108
PMCID: PMC3241756

Genes

EGFR
EGF
MMP7
ADAM12

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22089237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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