Article
Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
Circulation. Cardiovascular genetics - 1 Apr 2013
Pereira Naveen L, Lin Dong, Pelleymounter Linda, Moon Irene, Stilling Gail, Eckloff Bruce W, Wieben Eric D, Redfield Margaret M, Burnett John C, Yee Vivien C, Weinshilboum Richard M
Abstract excerpt
BACKGROUND- The primary role of natriuretic peptide receptor-3 (NPR3) or NPR-C is in the clearance of natriuretic peptides that play an important role in modulating intravascular volume and vascular tone. Genetic variation in NPR3 has been associated with variation in blood pressure and obesity. Despite the importance of NPR3, sequence variation in the gene has not been addressed using DNA from different ethnic...
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