Article
Atrial natriuretic peptide genetic variant rs5065 and risk for cardiovascular disease in the general community: a 9-year follow-up study.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2013
Cannone Valentina, Huntley Brenda K, Olson Timothy M, Heublein Denise M, Scott Christopher G, Bailey Kent R, Redfield Margaret M, Rodeheffer Richard J, Burnett John C
Abstract excerpt
We analyzed the phenotype associated with the atrial natriuretic peptide (ANP) genetic variant rs5065 in a random community-based sample. We also assessed and compared the biological action of 2 concentrations (10(-10) mol/L, 10(-8) mol/L) of ANP and ANP-RR, the protein variant encoded by the minor allele of rs5065, on activation of the guanylyl cyclase (GC)-A and GC-B receptors, production of the second...
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