Article
The Xenopus homeobox gene pitx3 impinges upon somitogenesis and laterality.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Apr 2013
Smoczer Cristine, Hooker Lara, Brode Sarah, Wolanski Marian, KhosrowShahian Farhad, Crawford Michael
Abstract excerpt
Pitx3 has been identified as the causative locus in a developmental eye mutation associated with mammalian anterior segment dysgenesis, congenital cataracts, and aphakia. In recent studies of frog eye development we discovered that pitx3 expresses symmetrically in the somites and lateral plate mesoderm and asymmetrically during cardiac and gut looping. We report that disruption of pitx3 activity on one side of an...
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