Article
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.
Developmental biology - 1 Dec 2007
Barrow Jeffery R, Howell William D, Rule Michael, Hayashi Shigemi, Thomas Kirk R, Capecchi Mario R, McMahon Andrew P
Abstract excerpt
The establishment of anteroposterior (AP) polarity in the early mouse epiblast is crucial for the initiation of gastrulation and the subsequent formation of the embryonic (head to tail) axis. The localization of anterior and posterior determining genes to the appropriate region of the embryo is a dynamic process that underlies this early polarity. Several studies indicate that morphological and molecular markers...
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