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Article

Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis.

Development (Cambridge, England) - 1 Sept 2009

Smith April N, Miller Leigh-Anne, Radice Glenn, Ashery-Padan Ruth, Lang Richard A

Abstract excerpt

The transcription factors Pax6 and Sox2 have been implicated in early events in lens induction and have been proposed to cooperate functionally. Here, we investigated the activity of Sox2 in lens induction and its genetic relationship to Pax6 in the mouse. Conditional deletion of Sox2 in the lens placode arrests lens development at the pit stage. As previously shown, conditional deletion of Pax6 in the placode...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19666824
DOI: 10.1242/dev.037341
PMCID: PMC2723069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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