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Article

Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells.

Mechanisms of development - 1 Jan 2000

Ho Hsin-Yi, Chang Kuo-Hsuan, Nichols Jennifer, Li Meng

Abstract excerpt

Pitx3 is a bicoid like homeobox transcription factor of which deficiency in mice is linked with the aphakia phenotype. Mutation in human PITX3 gene is associated with autosomal dominant cataract with variable anterior segment mesenchymal dysgenesis. However, the molecular events causing the morphological changes in aphakia remains unknown. In this study we investigated the behaviour of GFP tagged Pitx3 null...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19007884
DOI: 10.1016/j.mod.2008.10.007

Genes

PITX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells.PMID 19007884Read ↗

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A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice.Semantic proximity Read ↗

Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19.Semantic proximity Read ↗

The Xenopus homeobox gene pitx3 impinges upon somitogenesis and laterality.Semantic proximity Read ↗

Transcription factor GATA‐3 is essential for lens developmentSemantic proximity Read ↗

Functional analysis of human mutations in homeodomain transcription factor PITX3.Semantic proximity Read ↗

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Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.Semantic proximity Read ↗

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