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Article

A single disulfide bond disruption in the β3 integrin subunit promotes thiol/disulfide exchange, a molecular dynamics study.

PloS one - 1 Jan 2013

Levin Lihie, Zelzion Ehud, Nachliel Esther, Gutman Menachem, Tsfadia Yossi, Einav Yulia

Abstract excerpt

The integrins are a family of membrane receptors that attach a cell to its surrounding and play a crucial function in cell signaling. The combination of internal and external stimuli alters a folded non-active state of these proteins to an extended active configuration. The β3 subunit of the platelet αIIbβ3 integrin is made of well-structured domains rich in disulfide bonds. During the activation process some of...

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Identifiers

PMID: 23527123
DOI: 10.1371/journal.pone.0059175
PMCID: PMC3601072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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