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Article

The 95RGD97 sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor.

International journal of nanomedicine - 1 Jan 2018

Carvalho Filomena A, Guedes Ana Filipa, Duval Cedric, Macrae Fraser L, Swithenbank Luke, Farrell David H, Ariëns Robert As, Santos Nuno C

Abstract excerpt

BACKGROUND: Erythrocyte aggregation, a cardiovascular risk factor, is increased by high plasma fibrinogen levels. Here, the effect of different fibrinogen mutations on binding to its human erythrocyte receptor was assessed in order to identify the interaction sites. METHODS: Three fibrinogen variants were tested, specifically mutated in their putative integrin recognition sites on the Aα chain (mutants D97E,...

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Share to Binding Sites
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibrinogen

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Source

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Identifiers

PMID: 29662311
DOI: 10.2147/IJN.S154523
PMCID: PMC5892956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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