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Article

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function.

Blood - 14 Oct 2021

Pijning Aster E, Blyth Mitchell T, Coote Michelle L, Passam Freda, Chiu Joyce, Hogg Philip J

Abstract excerpt

The αIIbβ3 integrin receptor coordinates platelet adhesion, activation, and mechanosensing in thrombosis and hemostasis. Using differential cysteine alkylation and mass spectrometry, we have identified a disulfide bond in the αIIb subunit linking cysteines 490 and 545 that is missing in ∼1 in 3 integrin molecules on the resting and activated human platelet surface. This alternate covalent form of αIIbβ3 is...

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Source

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Identifiers

PMID: 34375384
DOI: 10.1182/blood.2021012441
PMCID: PMC8532129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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