Article
A molecular dynamics simulation of the human lysozyme - camelid VHH HL6 antibody system.
International journal of molecular sciences - 17 Apr 2009
Su Zhi-Yuan, Wang Yeng-Tseng
Abstract excerpt
Amyloid diseases such as Alzheimer's and thrombosis are characterized by an aberrant assembly of specific proteins or protein fragments into fibrils and plaques that are deposited in various tissues and organs. The single-domain fragment of a camelid antibody was reported to be able to combat against wild-type human lysozyme for inhibiting in-vitro aggregations of the amyloidogenic variant (D67H). The present...
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