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Article

Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design.

The Journal of biological chemistry - 3 Dec 2010

Donald Jason E, Zhu Hua, Litvinov Rustem I, DeGrado William F, Bennett Joel S

Abstract excerpt

Protein-protein interfaces are usually large and complementary surfaces, but specific side chains, representing energetic "hot spots," often contribute disproportionately to binding free energy. We used a computational method, comprehensive interface design, to identify hot spots in the interface between the stalk regions of the β3 and the complementary αIIb and αv integrin subunits. Using the Rosetta...

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Identifiers

PMID: 20929856
DOI: 10.1074/jbc.M110.170670
PMCID: PMC2992298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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