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Article

Natural and artificial mutations in αIIb integrin lead to a structural deformation of a calcium-binding site.

The protein journal - 1 Oct 2014

Mansour Wissam, Hauschner Hagit, Seligsohn Uri, Rosenberg Nurit, Einav Yulia

Abstract excerpt

The platelet integrin αIIbβ3 is widely accepted as a structural and a functional model of the broad integrin protein family. The four calcium-binding sites in the αIIb subunit contribute to biogenesis and stability of the protein. Mansour et al. (J Thromb Haemost 9:192-200, 2011) showed that the natural Asn2Asp mutation causing Glanzmann thrombasthenia, prevented surface expression of αIIbβ3, whereas the...

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PMID: 25216802
DOI: 10.1007/s10930-014-9579-5

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Natural and artificial mutations in αIIb integrin lead to a structural deformation of a calcium-binding site.PMID 25216802Read ↗

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