Article
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
The Journal of biological chemistry - 12 Mar 2004
Luo Bing-Hao, Takagi Junichi, Springer Timothy A
Abstract excerpt
Although integrin alpha subunit I domains exist in multiple conformations, it is controversial whether integrin beta subunit I-like domains undergo structurally analogous movements of the alpha7-helix that are linked to affinity for ligand. Disulfide bonds were introduced into the beta(3) integrin I-like domain to lock its beta6-alpha7 loop and alpha7-helix in two distinct conformations. Soluble ligand binding,...
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