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Article

The role of protein disulfide isomerase in the post-ligation phase of β3 integrin-dependent cell adhesion.

Thrombosis research - 1 Dec 2015

Leader Avi, Mor-Cohen Ronit, Ram Ron, Sheptovitsky Vera, Seligsohn Uri, Rosenberg Nurit, Lahav Judith

Abstract excerpt

INTRODUCTION: Protein disulfide isomerase (PDI) catalyzes disulfide bond exchange. It is crucial for integrin-mediated platelet adhesion and aggregation and disulfide bond exchange is necessary for αIIbβ3 and αvβ3 activation. However, the role of disulfide bond exchange and PDI in the post-ligation phase of αIIbβ3 and αvβ3 mediated cell adhesion has yet to be determined. METHODS: To investigate a possible such...

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Identifiers

PMID: 26514956
DOI: 10.1016/j.thromres.2015.10.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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