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Article

Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient.

BMC cancer - 22 Mar 2013

Zhang Jian, Shi Yuhao, Lalonde Emilie, Li Lili, Cavallone Luca, Ferenczy Alex, Gotlieb Walter H, Foulkes William D, Majewski Jacek

Abstract excerpt

BACKGROUND: Ovarian carcinoma is a common, and often deadly, gynecological cancer. Mutations in BRCA1 and BRCA2 genes are present in at least a fifth of patients. Uncovering other genes that become mutated subsequent to BRCA1/BRCA2 inactivation during cancer development will be helpful for more effective treatments. METHODS: We performed exome sequencing on the blood, primary tumor, omental metastasis and...

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Topics

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23522120
DOI: 10.1186/1471-2407-13-146
PMCID: PMC3614563

Genes

BRCA1
BRCA2
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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