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Article

Molecular profiles of BRCA1-associated ovarian cancer treated by platinum-based therapy: Analysis of primary, residual and relapsed tumors.

International journal of cancer - 1 Apr 2020

Sokolenko Anna P, Bizin Ilya V, Preobrazhenskaya Elena V, Gorodnova Tatiana V, Ivantsov Alexander O, Iyevleva Aglaya G, Savonevich Elena L, Kotiv Khristina B, Kuligina Ekaterina Sh, Imyanitov Evgeny N

Abstract excerpt

Our study aimed to analyze the evolution of molecular portraits of BRCA1-driven ovarian cancer (OC) during treatment. BRCA1 loss-of-heterozygosity status (LOH) and exome profiles were investigated in serial OC samples from 13 patients, which included primary tumors (n = 11) obtained before neoadjuvant therapy (NACT) or at primary debulking surgery, residual post-NACT cancer tissues (n = 13) and tumor relapses (16...

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Identifiers

PMID: 31693165
DOI: 10.1002/ijc.32776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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