Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.

Nature - 2 May 2013

Murtaza Muhammed, Dawson Sarah-Jane, Tsui Dana W Y, Gale Davina, Forshew Tim, Piskorz Anna M, Parkinson Christine, Chin Suet-Feung, Kingsbury Zoya, Wong Alvin S C, Marass Francesco, Humphray Sean, Hadfield James, Bentley David, Chin Tan Min, Brenton James D, Caldas Carlos, Rosenfeld Nitzan

Abstract excerpt

Cancers acquire resistance to systemic treatment as a result of clonal evolution and selection. Repeat biopsies to study genomic evolution as a result of therapy are difficult, invasive and may be confounded by intra-tumour heterogeneity. Recent studies have shown that genomic alterations in solid cancers can be characterized by massively parallel sequencing of circulating cell-free tumour DNA released from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Ovarian Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to Plasma

Share to Retinoblastoma Protein

Source

Identifiers

PMID: 23563269
DOI: 10.1038/nature12065

Genes

EGFR
GAS6
MED1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.PMID 23563269Read ↗

Treatment response and tumor evolution: lessons from an extended series of multianalyte liquid biopsies in a metastatic breast cancer patient.Semantic proximity Read ↗

Non-Invasive Analysis of Acquired Resistance to Cancer Therapy By Sequencing of Plasma DnaSemantic proximity Read ↗

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNASemantic proximity Read ↗

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancerSemantic proximity Read ↗

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.Semantic proximity Read ↗

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.Semantic proximity Read ↗

The landscape of actionable genomic alterations in cell-free circulating tumor DNA from 21,807 advanced cancer patientsSemantic proximity Read ↗

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients.Semantic proximity Read ↗

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.Semantic proximity Read ↗

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated <i>KDR</i> /VEGFR2 receptors as modulators of anti-angiogenic therapiesSemantic proximity Read ↗

Real-World Use of Highly Sensitive Liquid Biopsy Monitoring in Metastatic Breast Cancer Patients Treated with Endocrine Agents after Exposure to Aromatase Inhibitors.Semantic proximity Read ↗

Serial Plasma Comprehensive Genomic Profiling Captures Therapy Resistance and Guides Management of Non-Small Cell Lung Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.