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Article

Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations.

Journal of neuro-oncology - 1 Jul 2017

Balendran S, Liebmann-Reindl S, Berghoff A S, Reischer T, Popitsch N, Geier C B, Kenner L, Birner P, Streubel B, Preusser M

Abstract excerpt

Ovarian cancer represents the most common gynaecological malignancy and has the highest mortality of all female reproductive cancers. It has a rare predilection to develop brain metastases (BM). In this study, we evaluated the mutational profile of ovarian cancer metastases through Next-Generation Sequencing (NGS) with the aim of identifying potential clinically actionable genetic alterations with options for...

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Source

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Identifiers

PMID: 28497333
DOI: 10.1007/s11060-017-2459-z
PMCID: PMC5537326

Genes

ATM
BRCA1
BRCA2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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