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Article

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

Aging cell - 1 Aug 2013

Rahman Mohammed Mahidur, Sykiotis Gerasimos P, Nishimura Mayuko, Bodmer Rolf, Bohmann Dirk

Abstract excerpt

Aging is a degenerative process characterized by declining molecular, cell and organ functions, and accompanied by the progressive accumulation of oxidatively damaged macromolecules. This increased oxidative damage may be causally related to an age-associated dysfunction of defense mechanisms, which effectively protect young individuals from oxidative insults. Consistently, older organisms are more sensitive to...

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PMID: 23521918
DOI: 10.1111/acel.12078
PMCID: PMC3714369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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