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Article

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance.

Science translational medicine - 9 Apr 2014

Hecker Louise, Logsdon Naomi J, Kurundkar Deepali, Kurundkar Ashish, Bernard Karen, Hock Thomas, Meldrum Eric, Sanders Yan Y, Thannickal Victor J

Abstract excerpt

The incidence and prevalence of pathological fibrosis increase with advancing age, although mechanisms for this association are unclear. We assessed the capacity for repair of lung injury in young (2 months) and aged (18 months) mice. Whereas the severity of fibrosis was not different between these groups, aged mice demonstrated an impaired capacity for fibrosis resolution. Persistent fibrosis in lungs of aged...

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Source

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Identifiers

PMID: 24718857
DOI: 10.1126/scitranslmed.3008182
PMCID: PMC4545252

Genes

NFE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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