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Article

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2011

Kobayashi Akira, Tsukide Takako, Miyasaka Tomohiro, Morita Tomoko, Mizoroki Tatsuya, Saito Yoshiro, Ihara Yasuo, Takashima Akihiko, Noguchi Noriko, Fukamizu Akiyoshi, Hirotsu Yosuke, Ohtsuji Makiko, Katsuoka Fumiki, Yamamoto Masayuki

Abstract excerpt

Cap'n'Collar (CNC) proteins heterodimerize with small Maf proteins and regulate the transcription of various genes. Small Maf-deficient mice develop severe neurodegeneration, and it remains unclear whether CNC proteins are involved in this process. In this study, we examined the contribution of Nrf1, one of the CNC proteins, to neuronal homeostasis in vivo. As Nrf1 gene knockout mice are embryonic lethal, we...

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Identifiers

PMID: 21554501
DOI: 10.1111/j.1365-2443.2011.01522.x

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