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Article

Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.

Biochimica et biophysica acta - 1 Oct 2008

Li Wenge, Yu Siwang, Liu Tong, Kim Jung-Hwan, Blank Volker, Li Hong, Kong A-N Tony

Abstract excerpt

Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf proteins (sMaf). Nrf2/sMaf heterodimer binds specifically to a cis-acting enhancer called antioxidant response element and initiates transcription of a battery of antioxidant and detoxification genes. Nrf2 possesses a NESzip motif...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18585411
DOI: 10.1016/j.bbamcr.2008.05.024
PMCID: PMC2570698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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