Article
Neuroendocrine and epithelial phenotypes in small-cell lung cancer: implications for metastasis and survival in patients.
British journal of cancer - 30 Apr 2013
Stovold R, Meredith S L, Bryant J L, Babur M, Williams K J, Dean E J, Dive C, Blackhall F H, White A
Abstract excerpt
BACKGROUND: Small-cell lung cancer (SCLC) has a very aggressive clinical course with early metastasis. This study investigated how the distinctive neuroendocrine characteristics contribute to disease progression and invasion in human SCLC. METHODS: The neuroendocrine phenotype (pro-opiomelanocortin (POMC)) was quantified by ELISA in blood samples from 43 SCLC patients. The neuroendocrine (POMC, chromogranin A,...
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