Article
Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo.
PloS one - 1 Jan 2016
Meredith Suzanne L, Bryant Jennifer L, Babur Muhammad, Riddell Philip W, Behrouzi Roya, Williams Kaye J, White Anne
Abstract excerpt
BACKGROUND: Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro-opiomelanocortin (POMC), correlated with worse overall survival in patients. However, the effect of treatment on these phenotypes is not understood. The current study...
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