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Article

Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.

Molecular cell - 4 Mar 2011

Jinek Martin, Coyle Scott M, Doudna Jennifer A

Abstract excerpt

Messenger RNA decay plays a central role in the regulation and surveillance of eukaryotic gene expression. The conserved multidomain exoribonuclease Xrn1 targets cytoplasmic RNA substrates marked by a 5' monophosphate for processive 5'-to-3' degradation by an unknown mechanism. Here, we report th...

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Identifiers

PMID: 21362555
DOI: 10.1016/j.molcel.2011.02.004
PMCID: PMC3090138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21362555-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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