Article
Establishment of a prediction algorithm for the Honghe minority group based on warfarin maintenance dose.
Pharmacogenomics - 1 Jul 2022
Qian Mengjiao, Zhao Huan, Lou Yunli, Wang Jing, Wang Sibo, Wang Zhongyin, Ou Haibo, Li Jun, Yang Fajian, Bai Lingying, Lv Hong, Peng Xuguan, Chen Xiao, Yang Xiubing
Abstract excerpt
Background:CYP2C9 and VKORC1 are important factors in warfarin metabolism. The authors explored the effects of these genetic polymorphisms and clinical factors on a warfarin maintenance dose and then established the prediction algorithm for Honghe minorities in China. Materials & methods: Quantitative fluorescence PCR determined the mutation frequency of CYP2C9 and VKORC1-1639 G>A alleles. The authors collected...
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