Article
Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2005
Mallya Sanjay M, Gallagher James J, Wild Yvette K, Kifor Olga, Costa-Guda Jessica, Saucier Kirsten, Brown Edward M, Arnold Andrew
Abstract excerpt
The properties of neoplastic proliferation and hormonal dysregulation are tightly linked in primary hyperparathyroidism (HPT). However, whether abnormal parathyroid proliferation is the cause or result of a shift in calcium-sensitive parathyroid hormonal regulation has been controversial. We addressed this issue by analyzing the temporal sequence of these fundamental abnormalities in a mouse model of primary HPT....
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