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Amplification and overexpression of the epidermal growth factor receptor gene in human renal‐cell carcinoma

15 Jun 1990

Abstract excerpt

We examined 22 cases of renal-cell carcinoma (RCC) for structural alterations of the epidermal growth factor receptor (EGFR) gene and found gene amplification in one case of high-stage-high-grade RCC. Dot blot analysis of the total RNA from tumorous and normal kidney tissues revealed overexpression of the EGFR gene in 12 of 20 (60%) cases of RCC. The highest expression was observed in the gene-amplified case. No...

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PMID: 2351482
DOI: 10.1002/ijc.2910450606

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