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Article

Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma

18 Feb 2011

Abstract excerpt

OBJECTIVE: Fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) has recently emerged as a critical event in the transformation and tumorigenicity of several murine and human tumors. This pathway could be a mechanism driving angiogenesis in patients with metastatic renal cell carcinoma (RCC). Membrane antigens such as FGFR expressed in RCC are attractive targets for new therapeutic and diagnostic...

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PMID: 21329481
DOI: 10.3109/00365599.2011.552436

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